Author(s): Jiansong Yang, Mingxiang Liao, Magang Shou, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker, Amin Rostami-Hodjegan Simcyp Limited, 

Amin Rostami-Hodjegan Physiologically-based pharmacokinetic (PBPK) models provide a framework for in vitro-in vivo extrapolation of metabolic drug clearance. Many of the concepts in PBPK can have

amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author 2011-11-01 Pris: 1769 kr. Häftad, 2014. Skickas inom 10-15 vardagar. Köp Biosimulation in Biomedical Research, Health Care and Drug Development av Erik Mosekilde, Olga Sosnovtseva, Amin Rostami … 2016-03-29 Amin Rostami‐Hodjegan. University of Sheffield, Section of Molecular Pharmacology and Pharmacogenetics, Division of Clinical Sciences, The Royal Hallamshire Hospital, Sheffield, Search for more papers by this author. Kim Wolff. 2003-10-01 Title: Prediction of Intestinal First-Pass Drug Metabolism VOLUME: 8 ISSUE: 7 Author(s):Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, United Kingdom.

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PRINCETON, NJ – May 29, 2018 – Certara ®, the global leader in model-informed drug development, regulatory science, health economic outcomes research, market access and real-world evidence services, today announced its participation in 28 Editorial supervision of Pharmacological Reviews is shared jointly with the British Pharmacological Society and the Scandinavian pharmacological societies.. BOARD OF PUBLICATIONS TRUSTEES Brahim Achour, 1, * Zubida M. Al-Majdoub, 1, * Amin Rostami-Hodjegan, 1,2 and Jill Barber 1. Full Text HTML Download PDF Article Metrics Choose Your Access Option. Permissions; Reprints *These authors contributed equally to this work. Title: Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions VOLUME: 9 ISSUE: 5 Author(s):Jiansong Yang, Mingxiang Liao, Magang Shou, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU Professor Amin Rostami‐Hodjegan, PharmD, PhD, FCP, Centre for Applied Pharmaceutical Research, Manchester Pharmacy School, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E‐mail: amin.rostami@manchester.ac.uk. Search for more papers by this author Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology.

in biomedical research, health care and drug development / [ed] Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan, Wien: Springer, 2012, s.

Narciso Couto, Zubida M. Al-Majdoub, Brahim Achour, Phillip C. Wright, Amin Rostami-Hodjegan and Jill Barber Abstract ABSTRACT: There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing), which can be facilitated by quantitative systems pharmacology (QSP) models. Amin Rostami-Hodjegan. Authors. Kilian Kelly.

Kairui Feng1, Robert H. Leary1, Michael Dunlavey1, Amin Rostami-Hodjegan1,2 1. Certara, USA; 2. University of Manchester, UK; email: kevin.feng@Certara.com USP 1 USP 2 USP 3 USP 4 Figure 1. In Vitro dissolution profiles (n=3) of nifedipine IR capsule in FaSSGF. FaSSGFst=FaSSGF at pH 1.6 with water, FaSSGFoj=FaSSGF at pH 3.4 with grapefruit juice

You can also search for this author in PubMed Google Scholar amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but lansoprazole does not cause clinically significant inhibition of CYP2C19 whereas omeprazole does. To investigate this apparent paradox, we evaluated omeprazole, esomeprazole, R -omeprazole, lansoprazole, and pantoprazole for their ability to function as Amin Rostami-Hodjegan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

This review provides a brief account of the current knowledge, pra … In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers. As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but lansoprazole does not cause clinically significant inhibition of CYP2C19 whereas omeprazole does. To investigate this apparent paradox, we evaluated omeprazole, esomeprazole, R -omeprazole, lansoprazole, and pantoprazole for their ability to function as amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author Amin Rostami-Hodjegan has filed for patents to protect the following inventions.
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This review provides a brief account of the current knowledge, pra … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers. In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … 2012-12-13 Rachel H. Rose1, Kevin Feng1, David B. Turner1, Amin Rostami-Hodjegan1,2, Masoud Jamei1 1. Simcyp Limited (a Certara Company), Sheffield, UK; 2. Manchester School of Pharmacy, University of Manchester, UK • Following a meal, physiological changes occur that … Amin Rostami-Hodjegan is the author of ADME (0.0 avg rating, 0 ratings, 0 reviews, published 2009) and Biosimulation in Biomedical Research, Health Care Amin Rostami-Hodjegan has filed for patents to protect the following inventions.

View author publications. You can also search for this author in PubMed Google Scholar amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but lansoprazole does not cause clinically significant inhibition of CYP2C19 whereas omeprazole does.
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Rachel H. Rose1, Kevin Feng1, David B. Turner1, Amin Rostami-Hodjegan1,2, Masoud Jamei1 1. Simcyp Limited (a Certara Company), Sheffield, UK; 2. Manchester School of Pharmacy, University of Manchester, UK • Following a meal, physiological changes occur that can impact upon drug absorption and elimination.

Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan, “ Prediction of Intestinal First-Pass Drug Metabolism”, Current Drug AAPS J. 2016 Sep;18(5):1082-94. doi: 10.1208/s12248-016-9959-1. Review.